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HNRPF Antibody (Center)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP1703c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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- Backgrounds
HNRPF Antibody (Center) - Product info | |
| Application | WB, IHC
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| Primary Accession | P52597 |
| Other Accession | Q794E4, Q9Z2X1, Q60HC3, Q5E9J1 |
| Reactivity | Human |
| Predicted | Bovine, Mouse, Monkey, Rat |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 45672 Da |
HNRPF Antibody (Center) - Additional info | |
| Gene ID 3185 | |
| Other Names HNRNPF; HNRPF; Heterogeneous nuclear ribonucleoprotein F; Nucleolin-like protein mcs94-1; Heterogeneous nuclear ribonucleoprotein F, N-terminally processed | |
| Target/Specificity This HNRPF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 179~208 amino acids from the Center region of human HNRPF. | |
| Dilution WB~~1:50~100WB~~1:1000 IHC~~1:50~100 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions HNRPF Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
HNRPF Antibody (Center) - Protein Information | |
| Name HNRNPF | |
| Synonyms HNRPF | |
| Function Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state | |
| Cellular Location Nucleus, nucleoplasm. | |
| Tissue Location Expressed ubiquitously. | |
HNRPF Antibody (Center) - Related products
AP1703c: HNRPF Antibody (Center)
RI12528: HNRNPF predesign siRNA
DC01431: Human HNRNPF cDNA Clone
HNRPF Antibody (Center) - Application data
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Western blot analysis of HNRPF antibody (Center) (Cat.#AP1703c) in HepG2, Hela, K562 and A375 cell line lysates (35ug/lane). HNRPF (arrow) was detected using the purified Pab.
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Formalin-fixed and paraffin-embedded human brain tissue with HNRPF Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
HNRPF Antibody (Center) - Research Areas
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BACKGROUND
HNRPF belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein has three repeats of quasi-RRM domains that bind to RNAs which have guanosine-rich sequences.
REFERENCES
Chou,M.Y., Rooke,N. Mol. Cell. Biol. 19 (1), 69-77 (1999) Matunis,M.J., Xing,J. Nucleic Acids Res. 22 (6), 1059-1067 (1994) McDonald,H., Smailus,D. Genomics 13 (2), 344-348 (1992)
