|Application ||WB, E|
|Other Accession||Q6Q7Y5, P27601, NP_006563.2|
|Calculated MW||44050 Da|
|Antigen Region||184-212 aa|
|Other Names||Guanine nucleotide-binding protein subunit alpha-13, G alpha-13, G-protein subunit alpha-13, GNA13|
|Target/Specificity||This GNA13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 184-212 amino acids from the Central region of human GNA13.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GNA13 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.|
|Cellular Location||Membrane; Lipid-anchor. Melanosome. Cytoplasm. Nucleus. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Detected in the cytoplasm of Leydig cells and in the seminiferous epithelium, including differentiating cells from the spermatogonia to mature spermatozoa stages. In round spermatids, also present in the nuclei|
|Tissue Location||Expressed in testis, including in Leydig cells and in the seminiferous epithelium, in differentiating cells from the spermatogonia to mature spermatozoa stages and round spermatids (at protein level). Expressed in 99.2% of spermatozoa from healthy individuals, but only in 28.6% of macrocephalic spermatozoa from infertile patients (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Grzelinski, M., et al. Clin. Cancer Res. 16(5):1402-1415(2010)
Gong, H., et al. Science 327(5963):340-343(2010)
Saito, M., et al. Cell. Signal. 22(1):41-46(2010)
Chen, L., et al. J. Biol. Chem. 284(40):27409-27415(2009)
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