|Application ||WB, E|
|Other Accession||Q62376, Q1RMR2, NP_003080.2|
|Calculated MW||51557 Da|
|Antigen Region||195-223 aa|
|Other Names||U1 small nuclear ribonucleoprotein 70 kDa, U1 snRNP 70 kDa, U1-70K, snRNP70, SNRNP70, RNPU1Z, RPU1, SNRP70, U1AP1|
|Target/Specificity||This SNRNP70 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 195-223 amino acids from the Central region of human SNRNP70.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SNRNP70 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||RNPU1Z, RPU1, SNRP70, U1AP1|
|Function||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA.|
|Cellular Location||Nucleus. Nucleus speckle. Nucleus, nucleoplasm. Note=Colocalizes with SCNM1 and LUC7L2 in nuclear speckles.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
SNRNP70 mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA.
Spiluttini, B., et al. J. Cell. Sci. 123 (PT 12), 2085-2093 (2010) :
Tzang, B.S., et al. J. Biomed. Sci. 17, 40 (2010) :
Parente Costa, L., et al. J. Autoimmun. 33(2):121-124(2009)
Hernandez, H., et al. PLoS ONE 4 (9), E7202 (2009) :
Palafox Sanchez, C.A., et al. Arthritis Res. Ther. 11 (1), R27 (2009) :
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