|Application ||WB, E|
|Calculated MW||23306 Da|
|Antigen Region||189-218 aa|
|Other Names||Histone deacetylase complex subunit SAP30, 30 kDa Sin3-associated polypeptide, Sin3 corepressor complex subunit SAP30, Sin3-associated polypeptide p30, SAP30 (HGNC:10532)|
|Target/Specificity||This SAP30 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 189-218 amino acids from the C-terminal region of human SAP30.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Precautions||SAP30 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the functional recruitment of the Sin3- histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N- CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones.|
|Tissue Location||Expressed in all tissues tested with highest levels in pancreas, ovary, PBL, spleen and thymus; lowest levels in brain, placenta, lung and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq].
Brandt, S., et al. Int. J. Biochem. Cell Biol. 42(9):1472-1481(2010)
Viiri, K.M., et al. Mol. Cell. Biol. 29(2):342-356(2009)
Sichtig, N., et al. Arch. Biochem. Biophys. 467(1):67-75(2007)
Szafranski, K., et al. Genome Biol. 8 (8), R154 (2007) :
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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