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RRM2B Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - RRM2B Antibody (Center) AP17054c
    RRM2B Antibody (Center) (Cat. #AP17054c) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the RRM2B antibody detected the RRM2B protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q7LG56
Other Accession Q6PEE3, Q4R741, NP_001165948.1, NP_001165949.1
Reactivity Human
Predicted Monkey, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 40737 Da
Antigen Region 128-157 aa
Additional Information
Gene ID 50484
Other Names Ribonucleoside-diphosphate reductase subunit M2 B, TP53-inducible ribonucleotide reductase M2 B, p53-inducible ribonucleotide reductase small subunit 2-like protein, p53R2, RRM2B, P53R2
Target/Specificity This RRM2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 128-157 amino acids from the Central region of human RRM2B.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRRM2B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RRM2B
Synonyms P53R2
Function Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage.
Cellular Location Cytoplasm. Nucleus. Note=Translocates from cytoplasm to nucleus in response to DNA damage
Tissue Location Widely expressed at a high level in skeletal muscle and at a weak level in thymus. Expressed in epithelial dysplasias and squamous cell carcinoma
Research Areas
Citations (0)

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This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.


Zhou, B., et al. Mol. Cancer Ther. 9(6):1669-1679(2010)
Smith, P., et al. Biochemistry 48(46):11134-11141(2009)
Shaibani, A., et al. Arch. Neurol. 66(8):1028-1032(2009)
Tyynismaa, H., et al. Am. J. Hum. Genet. 85(2):290-295(2009)
Kollberg, G., et al. Neuromuscul. Disord. 19(2):147-150(2009)

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$ 295.00
$ 99.00
Cat# AP17054c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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