|Application ||WB, E|
|Calculated MW||65173 Da|
|Antigen Region||16-43 aa|
|Other Names||Beta-catenin-like protein 1, Nuclear-associated protein, NAP, Testis development protein NYD-SP19, CTNNBL1, C20orf33|
|Target/Specificity||This CTNNBL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-43 amino acids from the N-terminal region of human CTNNBL1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CTNNBL1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.|
|Cellular Location||Isoform 1: Nucleus.|
|Tissue Location||Widely expressed with highest levels in skeletal muscle, placenta, heart, spleen, testis and thyroid|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene contains an acidic domain, a putative bipartite nuclear localization signal, a nuclear export signal, a leucine-isoleucine zipper, and phosphorylation motifs. In addition, the encoded protein contains Armadillo/beta-catenin-like repeats, which have been implicated in protein-protein interactions. Although the function of this protein has not been determined, the C-terminal portion of the protein has been shown to possess apoptosis-inducing activity. [provided by RefSeq].
Ichikawa, S., et al. J. Bone Miner. Res. 25(8):1821-1829(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Badiglian Filho, L., et al. Oncol. Rep. 21(2):313-320(2009)
Andreasen, C.H., et al. BMC Med. Genet. 10, 17 (2009) :
Vogel, C.I., et al. BMC Med. Genet. 10, 14 (2009) :
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