|Application ||WB, E|
|Other Accession||Q9JM58, NP_004741.1|
|Calculated MW||46302 Da|
|Antigen Region||255-283 aa|
|Other Names||Cytokine receptor-like factor 1, Cytokine-like factor 1, CLF-1, ZcytoR5, CRLF1|
|Target/Specificity||This CRLF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 255-283 amino acids from the Central region of human CRLF1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Precautions||CRLF1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cytokine receptor subunit, possibly playing a regulatory role in the immune system and during fetal development. May be involved in nervous system development.|
|Tissue Location||Highest levels of expression observed in spleen, thymus, lymph node, appendix, bone marrow, stomach, placenta, heart, thyroid and ovary. Strongly expressed also in fetal lung.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells. Mutations in this gene result in Crisponi syndrome and cold-induced sweating syndrome. [provided by RefSeq].
Tsuritani, K., et al. Calcif. Tissue Int. 86(1):47-57(2010)
Crisponi, L., et al. Am. J. Hum. Genet. 80(5):971-981(2007)
Dagoneau, N., et al. Am. J. Hum. Genet. 80(5):966-970(2007)
Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)
Heese, K., et al. J. Cell. Biochem. 91(5):1030-1042(2004)
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