|Application ||WB, E|
|Calculated MW||38364 Da|
|Antigen Region||208-235 aa|
|Other Names||Annexin A9, Annexin XXXI, Annexin-31, Annexin-9, Pemphaxin, ANXA9, ANX31|
|Target/Specificity||This ANXA9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 208-235 amino acids from the Central region of human ANXA9.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ANXA9 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Low affinity receptor for acetylcholine known to be targeted by disease-causing pemphigus vulgaris antibodies in keratinocytes.|
|Tissue Location||Expressed in the stratified squamous skin epithelium, but not in epithelia of other types (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
The annexins are a family of calcium-dependent phospholipid-binding proteins. Members of the annexin family contain 4 internal repeat domains, each of which includes a type II calcium-binding site. The calcium-binding sites are required for annexins to aggregate and cooperatively bind anionic phospholipids and extracellular matrix proteins. This gene encodes a divergent member of the annexin protein family in which all four homologous type II calcium-binding sites in the conserved tetrad core contain amino acid substitutions that ablate their function. However, structural analysis suggests that the conserved putative ion channel formed by the tetrad core is intact.
Kottgen, A., et al. Nat. Genet. 42(5):376-384(2010)
Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)
Goebeler, V., et al. FEBS Lett. 546 (2-3), 359-364 (2003) :
Nguyen, V.T., et al. J. Biol. Chem. 275(38):29466-29476(2000)
Morgan, R.O., et al. Gene 227(1):33-38(1999)
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