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SERINC3 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - SERINC3 Antibody (C-term) AP17065b
    SERINC3 Antibody (C-term) (Cat. #AP17065b) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the SERINC3 antibody detected the SERINC3 protein (arrow).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q13530
Other Accession Q9QZI9, NP_945179.1, NP_006802.1
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 52580 Da
Antigen Region 373-400 aa
Additional Information
Gene ID 10955
Other Names Serine incorporator 3, Tumor differentially expressed protein 1, SERINC3, DIFF33, TDE1
Target/Specificity This SERINC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 373-400 amino acids from the C-terminal region of human SERINC3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSERINC3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SERINC3
Synonyms DIFF33, TDE1 {ECO:0000303|PubMed:1055979
Function Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734).
Cellular Location Cell membrane {ECO:0000250|UniProtKB:Q86VE9}; Multi-pass membrane protein. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9QZI9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9QZI9}
Tissue Location Ubiquitous. Expression levels were increased fourfold to tenfold in lung tumor tissues compared with normal pulmonary tissues.
Research Areas
Citations (0)

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Background

SERINC3 may be involved in cellular transformation.

References

Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Bossolasco, M., et al. Oncogene 25(33):4549-4558(2006)
Deloukas, P., et al. Nature 414(6866):865-871(2001)
Bossolasco, M., et al. Mol. Carcinog. 26(3):189-200(1999)
Adams, M.D., et al. Nature 377 (6547 SUPPL), 3-174 (1995) :

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Cat# AP17065b
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(40 western blots)
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