|Application ||WB, E|
|Other Accession||B4F7A7, Q8CEE0, NP_055494.2|
|Calculated MW||57089 Da|
|Antigen Region||89-117 aa|
|Other Names||Centrosomal protein of 57 kDa, Cep57, FGF2-interacting protein, Testis-specific protein 57, Translokin, CEP57, KIAA0092, TSP57|
|Target/Specificity||This CEP57 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-117 amino acids from the N-terminal region of human CEP57.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CEP57 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring- like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1.|
|Cellular Location||Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome|
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Provided below are standard protocols that you may find useful for product applications.
Translokin binds basic fibroblast growth factor (FGF2; MIM 134920) and mediates its nuclear translocation and mitogenic activity (Bossard et al., 2003 [PubMed 12717444]).[supplied by OMIM].
Bailey, S.D., et al. Diabetes Care (2010) In press :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Petretti, C., et al. EMBO Rep. 7(4):418-424(2006)
Kim, Y.S., et al. Biol. Reprod. 70(1):106-113(2004)
Andersen, J.S., et al. Nature 426(6966):570-574(2003)
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