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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   RAPGEF5 Antibody (C-term)   

RAPGEF5 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - RAPGEF5 Antibody (C-term) AP17073b
    RAPGEF5 Antibody (C-term) (Cat. #AP17073b) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the RAPGEF5 antibody detected the RAPGEF5 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q92565
Other Accession NP_036426.3
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 67733 Da
Antigen Region 529-555 aa
Additional Information
Gene ID 9771
Other Names Rap guanine nucleotide exchange factor 5, Guanine nucleotide exchange factor for Rap1, M-Ras-regulated Rap GEF, MR-GEF, Related to Epac, Repac, RAPGEF5, GFR, KIAA0277, MRGEF
Target/Specificity This RAPGEF5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 529-555 amino acids from the C-terminal region of human RAPGEF5.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRAPGEF5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms GFR, KIAA0277, MRGEF
Function Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation.
Cellular Location Nucleus.
Tissue Location Widely expressed with highest levels in brain.
Research Areas
Citations (0)

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Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Okada, Y., et al. Hum. Mol. Genet. 19(11):2303-2312(2010)
Hwang, S.J., et al. BMC Med. Genet. 8 SUPPL 1, S10 (2007) :
Rebhun, J.F., et al. J. Biol. Chem. 275(45):34901-34908(2000)
de Rooij, J., et al. J. Biol. Chem. 275(27):20829-20836(2000)

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$ 295.00
$ 99.00
Cat# AP17073b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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