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WHSC1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - WHSC1 Antibody (C-term) AP17079b
    All lanes : Anti-WHSC1 Antibody (C-term) at 1:2000 dilution Lane 1: Jurkat whole cell lysate Lane 2: Raji whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 152 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - WHSC1 Antibody (C-term) AP17079b
    WHSC1 Antibody (C-term) (Cat. #AP17079b) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the WHSC1 antibody detected the WHSC1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O96028
Other Accession Q8BVE8, NP_015627.1, NP_001035889.1
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 152258 Da
Antigen Region 1061-1089 aa
Additional Information
Gene ID 7468
Other Names Histone-lysine N-methyltransferase NSD2, Multiple myeloma SET domain-containing protein, MMSET, Nuclear SET domain-containing protein 2, NSD2, Protein trithorax-5, Wolf-Hirschhorn syndrome candidate 1 protein, WHSC1, WHSC1, KIAA1090, MMSET, NSD2, TRX5
Target/Specificity This WHSC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1061-1089 amino acids from the C-terminal region of human WHSC1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsWHSC1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name WHSC1
Synonyms KIAA1090, MMSET, NSD2, TRX5
Function Histone methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. Isoform RE-IIBP may act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00267, ECO:0000269|PubMed:15677557, ECO:0000269|PubMed:16197452}. Chromosome
Tissue Location Widely expressed.
Citations (0)

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This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4;14)(p16.3;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences.


Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Kang, H.B., et al. FEBS Lett. 583(12):1880-1886(2009)
Kassambara, A., et al. Biochem. Biophys. Res. Commun. 379(4):840-845(2009)
Brito, J.L., et al. Haematologica 94(1):78-86(2009)
Li, J., et al. Neuro-oncology 10(1):45-51(2008)

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$ 295.00
$ 99.00
Cat# AP17079b
(40 western blots)
Availability: In Stock
Bulk Size
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