|Application ||WB, IHC-P, FC, E|
|Calculated MW||21893 Da|
|Antigen Region||57-87 aa|
|Other Names||Interleukin-17D, IL-17D, Interleukin-27, IL-27, IL17D, IL27|
|Target/Specificity||This IL-27 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 57-87 amino acids from the Central region of human IL-27.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IL-27 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Induces expression of IL6, CXCL8/IL8, and CSF2/GM-CSF from endothelial cells.|
|Tissue Location||Expressed preferentially in adipose, skeletal muscle and CNS.|
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Provided below are standard protocols that you may find useful for product applications.
IL-27 is a cytokine that shares the sequence similarity with IL17. The treatment of endothelial cells with this cytokine has been shown to stimulate the production of other cytokines including IL6, IL8 and CSF2/ GM-CSF. The increased expression of IL8 induced by this cytokine was found to be NF-kappa B-dependent.
Clark, H.F., et al., Genome Res. 13(10):2265-2270 (2003).
Starnes, T., et al., J. Immunol. 169(2):642-646 (2002).
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