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CCL27 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9Y4X3 |
| Other Accession | NP_006655.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 12618 Da |
| Antigen Region | 74-102 aa |
| Gene ID | 10850 |
|---|---|
| Other Names | C-C motif chemokine 27, CC chemokine ILC, Cutaneous T-cell-attracting chemokine, CTACK, ESkine, IL-11 R-alpha-locus chemokine, Skinkine, Small-inducible cytokine A27, CCL27, ILC, SCYA27 |
| Target/Specificity | This CCL27 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 74-102 amino acids from the C-terminal region of human CCL27. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CCL27 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CCL27 |
|---|---|
| Synonyms | ILC, SCYA27 |
| Function | Chemotactic factor that attracts skin-associated memory T- lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. Binds to CCR10. |
| Cellular Location | Secreted {ECO:0000250|UniProtKB:Q9Z1X0}. |
| Tissue Location | Testis, thymus, placenta, ovary and skin. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to chemokine receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Siezen, C.L., et al. Pediatr. Infect. Dis. J. 28(4):333-335(2009)
Narbutt, J., et al. Mediators Inflamm. 2009, 269541 (2009) :
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