|Application ||WB, E|
|Calculated MW||23694 Da|
|Antigen Region||47-75 aa|
|Other Names||Tubulin polymerization-promoting protein, TPPP, 25 kDa brain-specific protein, TPPP/p25, p24, p25-alpha, TPPP, TPPP1|
|Target/Specificity||This TPPP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 47-75 amino acids from the Central region of human TPPP.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TPPP Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Localizes to glial Lewy bodies in the brains of individuals with synucleinopathies|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
TPPP may play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown.
Tokesi, N., et al. J. Biol. Chem. 285(23):17896-17906(2010)
McGovern, D.P., et al. Nat. Genet. 42(4):332-337(2010)
Sun, M., et al. Cell. Signal. 21(12):1857-1865(2009)
Ovadi, J., et al. Bioessays 31(6):676-686(2009)
Zhou, Y., et al. Leuk. Lymphoma 49(10):1945-1953(2008)
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