|Application ||WB, E|
|Calculated MW||60609 Da|
|Antigen Region||184-211 aa|
|Other Names||Tubby-related protein 1, Tubby-like protein 1, TULP1, TUBL1|
|Target/Specificity||This TULP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 184-211 amino acids from the Central region of human TULP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TULP1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long- term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells (By similarity). Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4- phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vitro). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages.|
|Cellular Location||Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Secreted. Cell junction, synapse. Note=Detected at synapses between photoreceptor cells and second-order neurons. Does not have a cleavable signal peptide and is secreted by an alternative pathway (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the tubby-like gene family (TULPs). Members of this family have been identified in plants, vertebrates, and invertebrates and encode proteins of unknown function. TULP proteins share a conserved C-terminal region of approximately 200 amino acid residues. Mutations in this gene may be associated with retinitis pigmentosa.
Clark, G.R., et al. Ophthalmology (2010) In press :
Caberoy, N.B., et al. Exp. Cell Res. 316(2):245-257(2010)
Abbasi, A.H., et al. Mol. Vis. 14, 675-682 (2008) :
Mataftsi, A., et al. Invest. Ophthalmol. Vis. Sci. 48(11):5160-5167(2007)
den Hollander, A.I., et al. Arch. Ophthalmol. 125(7):932-935(2007)
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