|Application ||WB, E|
|Other Accession||Q924M7, Q3SZI0, NP_002426.1|
|Calculated MW||46656 Da|
|Antigen Region||37-65 aa|
|Other Names||Mannose-6-phosphate isomerase, Phosphohexomutase, Phosphomannose isomerase, PMI, MPI, PMI1|
|Target/Specificity||This MPI antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-65 amino acids from the N-terminal region of human MPI.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MPI Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.|
|Tissue Location||Expressed in all tissues, but more abundant in heart, brain and skeletal muscle|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Phosphomannose isomerase catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate and plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions. Mutations in the MPI gene were found in patients with carbohydrate-deficient glycoprotein syndrome, type Ib.
Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Xiao, J., et al. J. Mol. Graph. Model. 25(3):289-295(2006)
Vuillaumier-Barrot, S., et al. J. Med. Genet. 39(11):849-851(2002)
Schollen, E., et al. Eur. J. Hum. Genet. 10(10):643-648(2002)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.