|Application ||WB, E|
|Other Accession||Q924M7, Q3SZI0, NP_002426.1|
|Calculated MW||46656 Da|
|Antigen Region||37-65 aa|
|Other Names||Mannose-6-phosphate isomerase, Phosphohexomutase, Phosphomannose isomerase, PMI, MPI, PMI1|
|Target/Specificity||This MPI antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-65 amino acids from the N-terminal region of human MPI.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MPI Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.|
|Tissue Location||Expressed in all tissues, but more abundant in heart, brain and skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
Phosphomannose isomerase catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate and plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions. Mutations in the MPI gene were found in patients with carbohydrate-deficient glycoprotein syndrome, type Ib.
Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Xiao, J., et al. J. Mol. Graph. Model. 25(3):289-295(2006)
Vuillaumier-Barrot, S., et al. J. Med. Genet. 39(11):849-851(2002)
Schollen, E., et al. Eur. J. Hum. Genet. 10(10):643-648(2002)
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