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EYA2 Antibody (Center)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP17094c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP17094c-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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EYA2 Antibody (Center) - Product info | |
| Application | WB
|
| Primary Accession | O00167 |
| Other Accession | NP_742108.2 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 59232 Da |
EYA2 Antibody (Center) - Additional info | |
| Gene ID 2139 | |
| Other Names EYA2; EAB1; Eyes absent homolog 2 | |
| Target/Specificity This EYA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 215-244 amino acids from the Central region of human EYA2. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions EYA2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
EYA2 Antibody (Center) - Protein Information | |
| Name EYA2 | |
| Synonyms EAB1 | |
| Function Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1. Seems to coactivate SIX2, SIX4 and SIX5. Together with SIX1 and DACH2 seem to be involved in myogenesis. May be involved in development of the eye. Interaction with GNAZ and GNAI2 prevents nuclear translocation and transcriptional activity | |
| Cellular Location Cytoplasm. Nucleus. | |
| Tissue Location Highest expression in muscle with lower levels in kidney, placenta, pancreas, brain and heart | |
EYA2 Antibody (Center) - Related products
AP17094c: EYA2 Antibody (Center)
DC02495: Human EYA2 cDNA Clone
LY10493a: EYA2 Over-expression Lysate
EYA2 Antibody (Center) - Application data
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EYA2 Antibody (Center) (Cat. #AP17094c) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the EYA2 antibody detected the EYA2 protein (arrow).
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Western blot analysis of EYA2 (arrow) using rabbit polyclonal EYA2 Antibody (Center) (Cat. #AP17094c). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the EYA2 gene.
EYA2 Antibody (Center) - Research Areas
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BACKGROUND
This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may be post-translationally modified and may play a role in eye development. A similar protein in mice can act as a transcriptional activator. Alternative splicing results in multiple transcript variants, but the full-length natures of all of these variants have not yet been determined.
REFERENCES
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) : Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010) Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009) Guo, J.T., et al. Zhonghua Zhong Liu Za Zhi 31(7):528-531(2009)
