|Application ||WB, E|
|Other Accession||Q7ZYG4, Q6P686, Q8MJ49, Q62422, Q6TGW5, Q5ZJJ9, Q8MJ50, NP_036515.4|
|Predicted||Bovine, Chicken, Zebrafish, Mouse, Pig, Rat, Xenopus|
|Calculated MW||23787 Da|
|Antigen Region||10-37 aa|
|Other Names||Osteoclast-stimulating factor 1, OSTF1|
|Target/Specificity||This OSTF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10-37 amino acids from the N-terminal region of human OSTF1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Precautions||OSTF1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.|
|Tissue Location||Ubiquitously expressed. Present in osteoclasts (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Osteoclast-stimulating factor-1 is an intracellular protein produced by osteoclasts that indirectly induces osteoclast formation and bone resorption (Reddy et al., 1998 [PubMed 10092216]).
Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :
Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)
Tong, S., et al. Proteins 75(1):245-251(2009)
Voss, M., et al. BMC Immunol. 10, 53 (2009) :
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
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