PDE7A Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q13946 |
Other Accession | O08593, P70453, NP_002594.1, NP_002595.1 |
Reactivity | Human |
Predicted | Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 55505 Da |
Antigen Region | 66-94 aa |
Gene ID | 5150 |
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Other Names | High affinity cAMP-specific 3', 5'-cyclic phosphodiesterase 7A, HCP1, TM22, PDE7A |
Target/Specificity | This PDE7A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-94 amino acids from the N-terminal region of human PDE7A. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PDE7A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PDE7A {ECO:0000303|PubMed:9195912, ECO:0000312|HGNC:HGNC:8791} |
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Function | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:8389765, PubMed:9195912, PubMed:19350606). May have a role in muscle signal transduction (PubMed:9195912). |
Cellular Location | [Isoform PDE7A1]: Cytoplasm, cytosol. Note=PDE7A1 (57 kDa) is located mostly to soluble cellular fractions. |
Tissue Location | [Isoform PDE7A1]: Found at high levels in skeletal muscle and at low levels in a variety of tissues including brain and heart (PubMed:9195912). It is expressed as well in two T-cell lines (PubMed:9195912). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.
References
Bailey, S.D., et al. Diabetes Care (2010) In press :
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Pekkinen, M., et al. Bone 43(1):84-91(2008)
Wang, H., et al. J. Biol. Chem. 280(35):30949-30955(2005)
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