|Application ||WB, E|
|Other Accession||NP_733932.1, NP_002234.2|
|Calculated MW||42577 Da|
|Antigen Region||339-367 aa|
|Other Names||ATP-sensitive inward rectifier potassium channel 15, Inward rectifier K(+) channel Kir13, Inward rectifier K(+) channel Kir42, Potassium channel, inwardly rectifying subfamily J member 15, KCNJ15, KCNJ14|
|Target/Specificity||This KCNJ15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 339-367 amino acids from the C-terminal region of human KCNJ15.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KCNJ15 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Three transcript variants encoding the same protein have been found for this gene.
Okamoto, K., et al. Am. J. Hum. Genet. 86(1):54-64(2010)
Sindic, A., et al. Am. J. Physiol. Renal Physiol. 297 (1), F36-F45 (2009) :
Ji, W., et al. Nat. Genet. 40(5):592-599(2008)
Huang, C., et al. Am. J. Physiol. Renal Physiol. 292 (3), F1073-F1081 (2007) :
Kubo, Y., et al. Pharmacol. Rev. 57(4):509-526(2005)
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