|Application ||WB, E|
|Other Accession||Q5BJS0, NP_055781.2, NP_619520.1|
|Calculated MW||133938 Da|
|Antigen Region||25-53 aa|
|Other Names||Putative ATP-dependent RNA helicase DHX30, DEAH box protein 30, DHX30, DDX30, KIAA0890|
|Target/Specificity||This DHX30 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-53 amino acids from the N-terminal region of human DHX30.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DHX30 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays an important role in the assembly of the mitochondrial large ribosomal subunit (PubMed:25683715). Required for optimal function of the zinc-finger antiviral protein ZC3HAV1 (By similarity). Associates with mitochondrial DNA (PubMed:18063578).|
|Cellular Location||Isoform 2: Cytoplasm. Mitochondrion. Cytoplasm. Mitochondrion matrix, mitochondrion nucleoid Note=Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids|
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Provided below are standard protocols that you may find useful for product applications.
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The encoded protein has 97% sequence identity with the mouse HELG protein. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Zhou, Y., et al. Virology 372(1):97-106(2008)
Bogenhagen, D.F., et al. J. Biol. Chem. 283(6):3665-3675(2008)
Takezawa, S., et al. EMBO J. 26(3):764-774(2007)
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