|Application ||WB, E|
|Calculated MW||45055 Da|
|Antigen Region||4-33 aa|
|Other Names||Bone morphogenetic protein 15, BMP-15, Growth/differentiation factor 9B, GDF-9B, BMP15, GDF9B|
|Target/Specificity||This Bmp15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-33 amino acids from the N-terminal region of human Bmp15.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Bmp15 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in follicular development. Oocyte- specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth.|
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Provided below are standard protocols that you may find useful for product applications.
Bmp15 is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The transforming growth factor-beta superfamily includes large families of growth and differentiation factors. It is thought that this protein may be involved in oocyte maturation and follicular development as a homodimer or by forming heterodimers with a related protein, Gdf9.
Liao, W.X., et al., J. Biol. Chem. 278(6):3713-3719 (2003).
Moore, R.K., et al., J. Biol. Chem. 278(1):304-310 (2003).
Galloway, S.M., et al., Nat. Genet. 25(3):279-283 (2000).
Aaltonen, J., et al., J. Clin. Endocrinol. Metab. 84(8):2744-2750 (1999).
Dube, J.L., et al., Mol. Endocrinol. 12(12):1809-1817 (1998).
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