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FBXL13 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8NEE6 |
| Other Accession | NP_001104508.1, NP_659469.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 83924 Da |
| Antigen Region | 683-710 aa |
| Gene ID | 222235 |
|---|---|
| Other Names | F-box/LRR-repeat protein 13, F-box and leucine-rich repeat protein 13, FBXL13, FBL13 |
| Target/Specificity | This FBXL13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 683-710 amino acids from the C-terminal region of human FBXL13. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FBXL13 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FBXL13 |
|---|---|
| Synonyms | DRC6 {ECO:0000250|UniProtKB:Q8CDU4}, FBL |
| Function | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Component of the nexin- dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Specifically targets CEP192 isoform 3 for ubiquitin-mediated proteolysis and thereby acts as a regulator of microtubule nucleation activity (PubMed:29348145). |
| Cellular Location | Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:A8JHD7}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome |
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Provided below are standard protocols that you may find useful for product applications.
Background
Members of the F-box protein family, such as FBXL13, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM].
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Curtiss, N.P., et al. Genomics 85(5):600-607(2005)
Jin, J., et al. Genes Dev. 18(21):2573-2580(2004)
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