|Application ||WB, E|
|Calculated MW||55820 Da|
|Antigen Region||94-122 aa|
|Other Names||Fibronectin type III and SPRY domain-containing protein 1, MID1-related protein 1, Microtubule-associated protein GLFND, FSD1, GLFND, MIR1|
|Target/Specificity||This FSD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 94-122 amino acids from the N-terminal region of human FSD1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FSD1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in microtubule organization and stabilization.|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cytoplasm. Cleavage furrow. Note=Cell-cycle-dependent association with the centrosome Colocalizes with a subpopulation of microtubules. Does not associates with microtubules during mitosis but reassociates with microtubules during cytokinesis. Localizes to the central portions of a small subset of microtubules in interphase cells and a subpopulation of microtubules in the cleavage furrow, not present in the mitotic spindle|
|Tissue Location||Highly expressed in brain tissues, including cerebellum, cerebral cortex, medulla, occipital pole, frontal lobe, temporal lobe and putamen. Lower expression in spinal chord|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a centrosome associated protein that is characterized by an N-terminal coiled-coil region downstream of B-box (BBC) domain, a central fibronectin type III domain, and a C-terminal repeats in splA and RyR (SPRY) domain. The encoded protein associates with a subset of microtubules and may be involved in the stability and organization of microtubules during cytokinesis.
Manabe, R., et al. Curr. Biol. 12(22):1946-1951(2002)
Stein, P.A., et al. J. Cell. Sci. 115 (PT 17), 3389-3402 (2002) :
Carim-Todd, L., et al. Biochim. Biophys. Acta 1518 (1-2), 200-203 (2001) :
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