|Application ||WB, E|
|Other Accession||F1MBP6, NP_059111.2|
|Calculated MW||64970 Da|
|Antigen Region||207-234 aa|
|Other Names||Kelch-like protein 3, KLHL3, KIAA1129|
|Target/Specificity||This KLHL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 207-234 amino acids from the Central region of human KLHL3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KLHL3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation.|
|Cellular Location||Cytoplasm, cytoskeleton. Cytoplasm, cytosol|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Schmutz, J., et al. Nature 431(7006):268-274(2004)
Yeo, A., et al. J. Neurochem. 76(6):1688-1700(2001)
Lai, F., et al. Genomics 66(1):65-75(2000)
Mizutani, A., et al. J. Biol. Chem. 275(13):9823-9831(2000)
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