|Application ||WB, E|
|Other Accession||Q5PQL5, Q99LH2, Q00576, Q2KHY9, NP_055569.1|
|Predicted||Bovine, Hamster, Mouse, Rat|
|Calculated MW||55528 Da|
|Antigen Region||390-418 aa|
|Other Names||Phosphatidylserine synthase 1, PSS-1, PtdSer synthase 1, Serine-exchange enzyme I, PTDSS1, KIAA0024, PSSA|
|Target/Specificity||This PTDSS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 390-418 amino acids from the C-terminal region of human PTDSS1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PTDSS1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. In membranes, PTDSS1 catalyzes mainly the conversion of phosphatidylcholine. Also converts, in vitro and to a lesser extent, phosphatidylethanolamine.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein Note=Highly enriched in the mitochondria-associated membrane (MAM).|
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Provided below are standard protocols that you may find useful for product applications.
Phosphatidylserine (PS) accounts for 5 to 10% of cell membrane phospholipids. In addition to its role as a structural component, PS is involved in cell signaling, blood coagulation, and apoptosis. PS is synthesized by a calcium-dependent base-exchange reaction catalyzed by PS synthases (EC 188.8.131.52), like PTDSS1, that exchange L-serine for the polar head group of phosphatidylcholine (PC) or phosphatidylethanolamine (PE) (Sturbois-Balcerzak et al., 2001 [PubMed 11084049]).
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Tomohiro, S., et al. Biochem. J. 418(2):421-429(2009)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Sturbois-Balcerzak, B., et al. J. Biol. Chem. 276(11):8205-8212(2001)
Stone, S.J., et al. J. Biol. Chem. 275(44):34534-34540(2000)
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