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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   ZFYVE27 Antibody (N-term)   

ZFYVE27 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - ZFYVE27 Antibody (N-term) AP17130A
    ZFYVE27 Antibody (N-term) (Cat. #AP17130a) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the ZFYVE27 antibody detected the ZFYVE27 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q5T4F4
Other Accession Q6P7B7, Q3TXX3, NP_001002261.1, NP_001002262.1
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 45843 Da
Antigen Region 28-56 aa
Additional Information
Gene ID 118813
Other Names Protrudin, Zinc finger FYVE domain-containing protein 27, ZFYVE27
Target/Specificity This ZFYVE27 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-56 amino acids from the N-terminal region of human ZFYVE27.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsZFYVE27 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZFYVE27
Function Functions as an upstream inhibitor of RAB11, regulating directional protein transport to the forming neurites. Involved in nerve growth factor-induced neurite formation. May have a more general role in cell projections formation.
Cellular Location Recycling endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell projection, growth cone membrane; Multi- pass membrane protein. Cell membrane; Multi-pass membrane protein Note=Localizes at both dendrites and axons.
Research Areas
Citations (0)

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Background

This gene encodes a protein with several transmembrane domains, a Rab11-binding domain and a lipid-binding FYVE finger domain. The encoded protein appears to promote neurite formation. A mutation in this gene has been reported to be associated with hereditary spastic paraplegia, however the pathogenicity of the mutation, which may simply represent a polymorphism, is unclear.

References

Saita, S., et al. J. Biol. Chem. 284(20):13766-13777(2009)
Martignoni, M., et al. Am. J. Hum. Genet. 83(1):127-128(2008)
Shirane, M., et al. Science 314(5800):818-821(2006)
Mannan, A.U., et al. Am. J. Hum. Genet. 79(2):351-357(2006)
Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)

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Cat# AP17130A
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Quantity:
(40 western blots)
Availability: In Stock
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