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ZFYVE27 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

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United States
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Ordering Information
Catalog # SizeAvailability Available Date  
AP17130A 400 µl
(40 western blots)
Backorder 4 months
AP17130A-ev 80 µl
(8 western blots)
Backorder 4 months
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ZFYVE27 Antibody (N-term) - Product info

Application
  • Applications Legend:
  • WB=Western Blotting
  • IP=Immunoprecipitation
  • IHC-P=Immunohistochemistry (Paraffin)
  • IF-IC=Immunofluorescence (Immunocytochemistry)
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary AccessionQ5T4F4
Other AccessionQ6P7B7, Q3TXX3, NP_001002261.1, NP_001002262.1
ReactivityHuman
PredictedMouse, Rat
IsotypeRabbit Ig
Calculated MW45843 Da

ZFYVE27 Antibody (N-term) - Additional info

Gene ID 118813
Other Names
ZFYVE27; Protrudin; Zinc finger FYVE domain-containing protein 27
Target/Specificity
This ZFYVE27 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-56 amino acids from the N-terminal region of human ZFYVE27.
Dilution
WB~~1:1000
Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions
ZFYVE27 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.

ZFYVE27 Antibody (N-term) - Protein Information

Name ZFYVE27
Function
Functions as an upstream inhibitor of RAB11, regulating directional protein transport to the forming neurites. Involved in nerve growth factor-induced neurite formation. May have a more general role in cell projections formation.
Cellular Location
Recycling endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell projection, growth cone membrane; Multi- pass membrane protein. Cell membrane; Multi-pass membrane protein Note=Localizes at both dendrites and axons (By similarity)

ZFYVE27 Antibody (N-term) - Related products

BP17130a: ZFYVE27 Antibody (N-term) Blocking Peptide

ZFYVE27 Antibody (N-term) - Research Areas

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BACKGROUND

This gene encodes a protein with several transmembrane domains, a Rab11-binding domain and a lipid-binding FYVE finger domain. The encoded protein appears to promote neurite formation. A mutation in this gene has been reported to be associated with hereditary spastic paraplegia, however the pathogenicity of the mutation, which may simply represent a polymorphism, is unclear.

REFERENCES

Saita, S., et al. J. Biol. Chem. 284(20):13766-13777(2009)
Martignoni, M., et al. Am. J. Hum. Genet. 83(1):127-128(2008)
Shirane, M., et al. Science 314(5800):818-821(2006)
Mannan, A.U., et al. Am. J. Hum. Genet. 79(2):351-357(2006)
Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)