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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   ZFYVE27 Antibody (N-term)   

ZFYVE27 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - ZFYVE27 Antibody (N-term) AP17130A
    ZFYVE27 Antibody (N-term) (Cat. #AP17130a) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the ZFYVE27 antibody detected the ZFYVE27 protein (arrow).
  • SPECIFICATION
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Product Information
ApplicationWB, E
Primary AccessionQ5T4F4
Other AccessionQ6P7B7, Q3TXX3, NP_001002261.1, NP_001002262.1
ReactivityHuman
PredictedMouse, Rat
HostRabbit
ClonalityPolyclonal
IsotypeRabbit Ig
Calculated MW45843 Da
Antigen Region28-56 aa
Additional Information
Gene ID118813
Other NamesProtrudin, Zinc finger FYVE domain-containing protein 27, ZFYVE27
Target/SpecificityThis ZFYVE27 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-56 amino acids from the N-terminal region of human ZFYVE27.
DilutionWB~~1:1000
FormatPurified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Protein Information
NameZFYVE27
Function Functions as an upstream inhibitor of RAB11, regulating directional protein transport to the forming neurites. Involved in nerve growth factor-induced neurite formation. May have a more general role in cell projections formation.
Cellular LocationRecycling endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell projection, growth cone membrane; Multi- pass membrane protein. Cell membrane; Multi-pass membrane protein Note=Localizes at both dendrites and axons.
Research Areas
Citations (0)

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Background

This gene encodes a protein with several transmembrane domains, a Rab11-binding domain and a lipid-binding FYVE finger domain. The encoded protein appears to promote neurite formation. A mutation in this gene has been reported to be associated with hereditary spastic paraplegia, however the pathogenicity of the mutation, which may simply represent a polymorphism, is unclear.

References

Saita, S., et al. J. Biol. Chem. 284(20):13766-13777(2009)
Martignoni, M., et al. Am. J. Hum. Genet. 83(1):127-128(2008)
Shirane, M., et al. Science 314(5800):818-821(2006)
Mannan, A.U., et al. Am. J. Hum. Genet. 79(2):351-357(2006)
Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)

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Cat# AP17130A
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Quantity:
(40 western blots)
Availability: In Stock
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