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CEACAM7 Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CEACAM7 Antibody (Center) AP17149C
    CEACAM7 Antibody (Center) (Cat. #AP17149c) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the CEACAM7 antibody detected the CEACAM7 protein (arrow).
    detail
  • IHC-P - CEACAM7 Antibody (Center) AP17149C
    CEACAM7 Antibody (Center) (AP17149c)immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CEACAM7 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
    detail
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, WB, E
Primary Accession Q14002
Other Accession NP_008821.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 29345 Da
Antigen Region 112-140 aa
Additional Information
Gene ID 1087
Other Names Carcinoembryonic antigen-related cell adhesion molecule 7, Carcinoembryonic antigen CGM2, CEACAM7, CGM2
Target/Specificity This CEACAM7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 112-140 amino acids from the Central region of human CEACAM7.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCEACAM7 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CEACAM7 (HGNC:1819)
Synonyms CGM2
Cellular Location Cell membrane; Lipid-anchor, GPI- anchor. Apical cell membrane. Note=Localized to the apical glycocalyx surface.
Tissue Location Expressed in columnar epithelial cells of the colon (at protein level) (PubMed:10436421). Strongly down-regulated in colonic adenocarcinomas.
Citations (0)
citation

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Background

CEA-related cell adhesion molecule 7 (CEACAM7,CGM2) belongs to the carcinoembryonic antigen (CEA) family. It encodes a glycosyl phosphatidyl inositol (GPI)-linked glycoprotein which is only found on the apical surface of highly differentiated epithelial cells adult colon and on a small epithelial cell population in pancreatic ducts. CEACAM7 expression is completely lost upon malignant transformation already in hyperplastic polyps and early adenomas as well as in adenocarcinomas of the colon. Like all members of the CEACAM family, it consists of a single N domain, with structural homology to the immunoglobulin variable domains, followed by one immunoglobulin constantlike A domain.

References

Messick, C.A., et al. Surgery 147(5):713-719(2010)
Douard, R., et al. Surgery 139(4):556-562(2006)
Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)
Grimwood, J., et al. Nature 428(6982):529-535(2004)
Scholzel, S., et al. Am. J. Pathol. 156(2):595-605(2000)

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$ 365.00
$ 140.00
Cat# AP17149C
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