|Application ||WB, IHC-P, E|
|Calculated MW||29379 Da|
|Antigen Region||112-140 aa|
|Other Names||Carcinoembryonic antigen-related cell adhesion molecule 7, Carcinoembryonic antigen CGM2, CEACAM7, CGM2|
|Target/Specificity||This CEACAM7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 112-140 amino acids from the Central region of human CEACAM7.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CEACAM7 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor|
|Tissue Location||Strongly down-regulated in colonic adenocarcinomas|
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Provided below are standard protocols that you may find useful for product applications.
CEA-related cell adhesion molecule 7 (CEACAM7,CGM2) belongs to the carcinoembryonic antigen (CEA) family. It encodes a glycosyl phosphatidyl inositol (GPI)-linked glycoprotein which is only found on the apical surface of highly differentiated epithelial cells adult colon and on a small epithelial cell population in pancreatic ducts. CEACAM7 expression is completely lost upon malignant transformation already in hyperplastic polyps and early adenomas as well as in adenocarcinomas of the colon. Like all members of the CEACAM family, it consists of a single N domain, with structural homology to the immunoglobulin variable domains, followed by one immunoglobulin constantlike A domain.
Messick, C.A., et al. Surgery 147(5):713-719(2010)
Douard, R., et al. Surgery 139(4):556-562(2006)
Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)
Grimwood, J., et al. Nature 428(6982):529-535(2004)
Scholzel, S., et al. Am. J. Pathol. 156(2):595-605(2000)
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