|Application ||WB, IHC-P, E|
|Calculated MW||53372 Da|
|Antigen Region||8-36 aa|
|Other Names||Bone morphogenetic protein 3, BMP-3, Bone morphogenetic protein 3A, BMP-3A, Osteogenin, BMP3, BMP3A|
|Target/Specificity||This Bmp3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-36 amino acids from the N-terminal region of human Bmp3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Bmp3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.|
|Tissue Location||Expressed in adult and fetal cartilage.|
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Provided below are standard protocols that you may find useful for product applications.
The BMPs belong to the TGF-Beta superfamilyBMPs stimulate the production of bone matrix proteins and thereby alter stromal cell and osteoclast proliferation, a key step in bone marrow development. In addition to promoting ectopic bone and cartilage development, BMPs regulate the growth, differentiation, chemotaxis, proliferation, and apoptosis of various cell types, including mesenchymal cells, epithelial cells, hematopoietic cells, and neuronal cells. BMPs also play a role in dorsal/ventral patterning. BMP3, highly expressed in lung, ovary and small intestine, participates in cartilage and bone formation. BMP3 and BMP2 genes map to conserved regions between human and mouse.
Jin, Y., et al., Histol. Histopathol. 16(4):1013-1019 (2001).
Tabas, J.A., et al., Genomics 9(2):283-289 (1991).
Dickinson, M.E., et al., Genomics 6(3):505-520 (1990).
Wozney, J.M., et al., Science 242(4885):1528-1534 (1988).
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