|Application ||WB, E|
|Other Accession||NP_001001486.1, NP_001001485.1|
|Calculated MW||100577 Da|
|Antigen Region||882-909 aa|
|Other Names||Calcium-transporting ATPase type 2C member 1, ATPase 2C1, ATP-dependent Ca(2+) pump PMR1, ATP2C1, KIAA1347, PMR1L|
|Target/Specificity||This ATP2C1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 882-909 amino acids from the C-terminal region of human ATP2C1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ATP2C1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium.|
|Cellular Location||Golgi apparatus membrane; Multi-pass membrane protein|
|Tissue Location||Found in most tissues except colon, thymus, spleen and leukocytes. Most abundant in keratinocytes and kidney|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder. Alternatively spliced transcript variants encoding different isoforms have been identified.
Baron, S., et al. Biochim. Biophys. Acta 1798(8):1512-1521(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Tian, H., et al. J. Dermatol. Sci. 58(1):80-82(2010)
Ding, Y.G., et al. Clin. Exp. Dermatol. 34 (8), E968-E971 (2009) :
Nechama, M., et al. BMC Cell Biol. 10, 70 (2009) :
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