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MXD1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q05195 |
| Other Accession | NP_002348.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 25254 Da |
| Antigen Region | 23-50 aa |
| Gene ID | 4084 |
|---|---|
| Other Names | Max dimerization protein 1, Max dimerizer 1, Protein MAD, MXD1, MAD |
| Target/Specificity | This MXD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 23-50 amino acids from the N-terminal region of human MXD1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MXD1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MXD1 |
|---|---|
| Synonyms | MAD |
| Function | Component of a transcriptional repressor complex together with MAX (PubMed:8425218). In complex with MAX binds to the core DNA sequence 5'-CAC[GA]TG-3' (PubMed:8425218). Antagonizes MYC transcriptional activity by competing with MYC for MAX binding (PubMed:8425218). Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding (PubMed:12837246). |
| Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
MAX dimerization protein belongs to a subfamily of MAX-interacting proteins. This protein competes with MYC for binding to MAX to form a sequence-specific DNA-binding complex, acts as a transcriptional repressor (while MYC appears to function as an activator) and is a candidate tumor suppressor. [provided by RefSeq].
References
Wu, S., et al. Exp. Cell Res. 315(18):3099-3111(2009)
Chou, C.K., et al. Mol. Carcinog. 48(11):1048-1058(2009)
Zhu, J., et al. Proc. Natl. Acad. Sci. U.S.A. 105(18):6584-6589(2008)
Jiang, K., et al. Nucleic Acids Res. 36(5):1517-1531(2008)
Suo, X.H., et al. Zhonghua Xue Ye Xue Za Zhi 28(11):745-749(2007)
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