|Application ||WB, E|
|Calculated MW||25254 Da|
|Antigen Region||23-50 aa|
|Other Names||Max dimerization protein 1, Max dimerizer 1, Protein MAD, MXD1, MAD|
|Target/Specificity||This MXD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 23-50 amino acids from the N-terminal region of human MXD1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MXD1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional repressor. MAD binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MAD thus antagonizes MYC transcriptional activity by competing for MAX.|
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Provided below are standard protocols that you may find useful for product applications.
MAX dimerization protein belongs to a subfamily of MAX-interacting proteins. This protein competes with MYC for binding to MAX to form a sequence-specific DNA-binding complex, acts as a transcriptional repressor (while MYC appears to function as an activator) and is a candidate tumor suppressor. [provided by RefSeq].
Wu, S., et al. Exp. Cell Res. 315(18):3099-3111(2009)
Chou, C.K., et al. Mol. Carcinog. 48(11):1048-1058(2009)
Zhu, J., et al. Proc. Natl. Acad. Sci. U.S.A. 105(18):6584-6589(2008)
Jiang, K., et al. Nucleic Acids Res. 36(5):1517-1531(2008)
Suo, X.H., et al. Zhonghua Xue Ye Xue Za Zhi 28(11):745-749(2007)
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