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DOK5 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - DOK5 Antibody (N-term) AP17160a
    DOK5 Antibody (N-term) (Cat. #AP17160a) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the DOK5 antibody detected the DOK5 protein (arrow).
  • WB - DOK5 Antibody (N-term) AP17160a
    Western blot analysis of DOK5 (arrow) using rabbit polyclonal DOK5 Antibody (N-term) (Cat. #AP17160a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the DOK5 gene.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9P104
Other Accession Q91ZM9, NP_060901.2
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 35464 Da
Antigen Region 21-49 aa
Additional Information
Gene ID 55816
Other Names Docking protein 5, Downstream of tyrosine kinase 5, Insulin receptor substrate 6, IRS-6, IRS6, DOK5, C20orf180
Target/Specificity This DOK5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-49 amino acids from the N-terminal region of human DOK5.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDOK5 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DOK5
Synonyms C20orf180
Function DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.
Tissue Location Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes.
Research Areas
Citations (0)

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The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. In contrast to other DOK family proteins, this protein does not interact with RASGAP.


Liu, X., et al. J Am Acad Child Adolesc Psychiatry 49(1):33-41(2010)
Tabassum, R., et al. BMC Med. Genet. 11, 35 (2010) :
Shi, L., et al. Cell. Signal. 18(11):1995-2003(2006)
Cai, D., et al. J. Biol. Chem. 278(28):25323-25330(2003)
Favre, C., et al. Genes Immun. 4(1):40-45(2003)

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Cat# AP17160a
(40 western blots)
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