|Application ||WB, E|
|Other Accession||P62255, P62254, Q4R5Y8, NP_003333.1|
|Predicted||Monkey, Mouse, Rat|
|Calculated MW||19509 Da|
|Antigen Region||127-155 aa|
|Other Names||Ubiquitin-conjugating enzyme E2 G1, E217K, UBC7, Ubiquitin carrier protein G1, Ubiquitin-protein ligase G1, Ubiquitin-conjugating enzyme E2 G1, N-terminally processed, UBE2G1, UBE2G|
|Target/Specificity||This UBE2G1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 127-155 amino acids from the C-terminal region of human UBE2G1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||UBE2G1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4.|
|Tissue Location||Widely expressed, mainly in skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins. The protein may be involved in degradation of muscle-specific proteins. [provided by RefSeq].
Hassink, G., et al. Biochem. J. 388 (PT 2), 647-655 (2005) :
Kim, B.W., et al. Mol. Endocrinol. 17(12):2603-2612(2003)
Gevaert, K., et al. Nat. Biotechnol. 21(5):566-569(2003)
Imai, Y., et al. Cell 105(7):891-902(2001)
Tiwari, S., et al. J. Biol. Chem. 276(19):16193-16200(2001)
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