|Application ||WB, E|
|Other Accession||Q25C79, B1AXD8, A8YXY8, NP_060534.1|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||22496 Da|
|Antigen Region||177-203 aa|
|Other Names||Akirin-2, AKIRIN2, C6orf166|
|Target/Specificity||This AKIRIN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 177-203 amino acids from the C-terminal region of human AKIRIN2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AKIRIN2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity).|
|Tissue Location||Widely expressed with the highest expression in peripheral blood leukocytes.|
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Provided below are standard protocols that you may find useful for product applications.
Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity).
Komiya, Y., et al. J. Biol. Chem. 283(27):18753-18764(2008)
Goto, A., et al. Nat. Immunol. 9(1):97-104(2008)
Levy, D., et al. BMC Med. Genet. 8 SUPPL 1, S3 (2007) :
Vasan, R.S., et al. BMC Med. Genet. 8 SUPPL 1, S2 (2007) :
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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