AKIRIN2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q53H80 |
Other Accession | Q25C79, B1AXD8, A8YXY8, NP_060534.1, A0A287BDC1 |
Reactivity | Human |
Predicted | Bovine, Mouse, Pig, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 22496 Da |
Antigen Region | 177-203 aa |
Gene ID | 55122 |
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Other Names | Akirin-2, AKIRIN2, C6orf166 |
Target/Specificity | This AKIRIN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 177-203 amino acids from the C-terminal region of human AKIRIN2. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | AKIRIN2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | AKIRIN2 {ECO:0000303|PubMed:18066067, ECO:0000312|HGNC:HGNC:21407} |
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Function | Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in embryonic development, immunity, myogenesis and brain development (PubMed:34711951). Plays a key role in nuclear protein degradation by promoting import of proteasomes into the nucleus: directly binds to fully assembled 20S proteasomes at one end and to nuclear import receptor IPO9 at the other end, bridging them together and mediating the import of pre-assembled proteasome complexes through the nuclear pore (PubMed:34711951). Involved in innate immunity by regulating the production of interleukin-6 (IL6) downstream of Toll-like receptor (TLR): acts by bridging the NF-kappa-B inhibitor NFKBIZ and the SWI/SNF complex, leading to promote induction of IL6 (By similarity). Also involved in adaptive immunity by promoting B-cell activation (By similarity). Involved in brain development: required for the survival and proliferation of cerebral cortical progenitor cells (By similarity). Involved in myogenesis: required for skeletal muscle formation and skeletal development, possibly by regulating expression of muscle differentiation factors (By similarity). Also plays a role in facilitating interdigital tissue regression during limb development (By similarity). |
Cellular Location | Nucleus. Cytoplasm {ECO:0000250|UniProtKB:B1AXD8} Membrane {ECO:0000250|UniProtKB:B1AXD8}. Note=Present mainly in the nuclear fraction, and at much lower level in the cytoplasmic and membrane fractions. {ECO:0000250|UniProtKB:B1AXD8} |
Tissue Location | Widely expressed with the highest expression in peripheral blood leukocytes. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity).
References
Komiya, Y., et al. J. Biol. Chem. 283(27):18753-18764(2008)
Goto, A., et al. Nat. Immunol. 9(1):97-104(2008)
Levy, D., et al. BMC Med. Genet. 8 SUPPL 1, S3 (2007) :
Vasan, R.S., et al. BMC Med. Genet. 8 SUPPL 1, S2 (2007) :
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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