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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   BCL7B Antibody (C-term)   

BCL7B Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - BCL7B Antibody (C-term) AP17168b
    BCL7B Antibody (C-term) (Cat. #AP17168b) western blot analysis in Y79 cell line lysates (35ug/lane).This demonstrates the BCL7B antibody detected the BCL7B protein (arrow).
  • WB - BCL7B Antibody (C-term) AP17168b
    BCL7B Antibody (C-term) (Cat. #AP17168b) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the BCL7B antibody detected the BCL7B protein (arrow).
  • IHC-P - BCL7B Antibody (C-term) AP17168b
    BCL7B Antibody (C-term) (AP17168b)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of BCL7B Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9BQE9
Other Accession Q921K9, Q3T0A6, NP_001698.2
Reactivity Human, Mouse
Predicted Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 22195 Da
Antigen Region 137-164 aa
Additional Information
Gene ID 9275
Other Names B-cell CLL/lymphoma 7 protein family member B, Hom s 3, BCL7B
Target/Specificity This BCL7B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 137-164 amino acids from the C-terminal region of human BCL7B.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBCL7B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BCL7B
Function Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1 (PubMed:25569233). Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation (PubMed:25569233). May play a role in lung tumor development or progression (By similarity).
Tissue Location Ubiquitous.
Research Areas
Citations (0)

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Background

This gene encodes a member of the BCL7 family including BCL7A, BCL7B and BCL7C proteins. This member is BCL7B, which contains a region that is highly similar to the N-terminal segment of BCL7A or BCL7C proteins. The BCL7A protein is encoded by the gene known to be directly involved in a three-way gene translocation in a Burkitt lymphoma cell line. This gene is located at a chromosomal region commonly deleted in Williams syndrome. This gene is highly conserved from C. elegans to human. Multiple alternatively spliced transcript variants have been found for this gene.

References

Fontaine-Bisson, B., et al. Diabetologia 53(10):2155-2162(2010)
Kathiresan, S., et al. Nat. Genet. 40(2):189-197(2008)
Willer, C.J., et al. Nat. Genet. 40(2):161-169(2008)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Jadayel, D.M., et al. Gene 224 (1-2), 35-44 (1998) :

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$ 295.00
$ 99.00
Cat# AP17168b
Size:
Quantity:
(40 western blots)
Availability: In Stock
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