|Application ||WB, IHC-P, E|
|Other Accession||Q921K9, Q3T0A6, NP_001698.2|
|Calculated MW||22195 Da|
|Antigen Region||137-164 aa|
|Other Names||B-cell CLL/lymphoma 7 protein family member B, Hom s 3, BCL7B|
|Target/Specificity||This BCL7B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 137-164 amino acids from the C-terminal region of human BCL7B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BCL7B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1 (PubMed:25569233). Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation (PubMed:25569233). May play a role in lung tumor development or progression (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the BCL7 family including BCL7A, BCL7B and BCL7C proteins. This member is BCL7B, which contains a region that is highly similar to the N-terminal segment of BCL7A or BCL7C proteins. The BCL7A protein is encoded by the gene known to be directly involved in a three-way gene translocation in a Burkitt lymphoma cell line. This gene is located at a chromosomal region commonly deleted in Williams syndrome. This gene is highly conserved from C. elegans to human. Multiple alternatively spliced transcript variants have been found for this gene.
Fontaine-Bisson, B., et al. Diabetologia 53(10):2155-2162(2010)
Kathiresan, S., et al. Nat. Genet. 40(2):189-197(2008)
Willer, C.J., et al. Nat. Genet. 40(2):161-169(2008)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Jadayel, D.M., et al. Gene 224 (1-2), 35-44 (1998) :
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