|Application ||WB, IHC-P, E|
|Calculated MW||51737 Da|
|Antigen Region||16-46 aa|
|Other Names||Bone morphogenetic protein 5, BMP-5, BMP5|
|Target/Specificity||This Bmp5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-46 amino acids from the N-terminal region of human Bmp5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Bmp5 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Induces cartilage and bone formation.|
|Tissue Location||Expressed in the lung and liver.|
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Provided below are standard protocols that you may find useful for product applications.
Bmp5 is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. These proteins are synthesized as prepropeptides, cleaved, and then processed into dimeric proteins. This protein may act as an important signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. This gene is differentially regulated during the formation of various tumors.
Luo, J., et al., Prostate 51(3):189-200 (2002).
Jin, Y., et al., Histol. Histopathol. 16(4):1013-1019 (2001).
Sakaue, M., et al., Biochem. Biophys. Res. Commun. 221(3):768-772 (1996).
Hahn, G.V., et al., Genomics 14(3):759-762 (1992).
Celeste, A.J., et al., Proc. Natl. Acad. Sci. U.S.A. 87(24):9843-9847 (1990).
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