- CITATIONS: 1
|Application ||WB, IHC-P, E|
|Calculated MW||57226 Da|
|Antigen Region||25-55 aa|
|Other Names||Bone morphogenetic protein 6, BMP-6, VG-1-related protein, VG-1-R, VGR-1, BMP6, VGR|
|Target/Specificity||This Bmp6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-55 amino acids from the N-terminal region of human Bmp6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Bmp6 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Induces cartilage and bone formation.|
Provided below are standard protocols that you may find useful for product applications.
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, Bmp6 has a proposed role in early development. In addition, the fact that BMP6 is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity.
Lories, R.J., et al., Arthritis Rheum. 48(10):2807-2818 (2003).
Bobacz, K., et al., Arthritis Rheum. 48(9):2501-2508 (2003).
Tamada, H., et al., Biochim. Biophys. Acta 1395(3):247-251 (1998).
Rickard, D.J., et al., J. Clin. Invest. 101(2):413-422 (1998).
Olavesen, M.G., et al., Genomics 46(2):303-306 (1997).
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