|Application ||WB, E|
|Calculated MW||24008 Da|
|Antigen Region||86-114 aa|
|Other Names||Troponin I, cardiac muscle, Cardiac troponin I, TNNI3, TNNC1|
|Target/Specificity||This TNNI3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-114 amino acids from the Central region of human TNNI3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TNNI3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.|
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Provided below are standard protocols that you may find useful for product applications.
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
Millat, G., et al. Clin. Chim. Acta 411 (23-24), 1983-1991 (2010) :
Murakami, C., et al. Leg Med (Tokyo) 12(6):280-283(2010)
Millat, G., et al. Eur J Med Genet 53(5):261-267(2010)
Di Chiara, A., et al. J Cardiovasc Med (Hagerstown) 11(8):587-592(2010)
Napan, S., et al. Coron. Artery Dis. 21(5):261-265(2010)
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