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TNNI3 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P19429 |
| Other Accession | NP_000354.4 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 24008 Da |
| Antigen Region | 86-114 aa |
| Gene ID | 7137 |
|---|---|
| Other Names | Troponin I, cardiac muscle, Cardiac troponin I, TNNI3, TNNC1 |
| Target/Specificity | This TNNI3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-114 amino acids from the Central region of human TNNI3. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TNNI3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TNNI3 |
|---|---|
| Synonyms | TNNC1 |
| Function | Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
References
Millat, G., et al. Clin. Chim. Acta 411 (23-24), 1983-1991 (2010) :
Murakami, C., et al. Leg Med (Tokyo) 12(6):280-283(2010)
Millat, G., et al. Eur J Med Genet 53(5):261-267(2010)
Di Chiara, A., et al. J Cardiovasc Med (Hagerstown) 11(8):587-592(2010)
Napan, S., et al. Coron. Artery Dis. 21(5):261-265(2010)
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