|Application ||WB, E|
|Other Accession||NP_001104778.1, NP_001104777.1|
|Calculated MW||98143 Da|
|Antigen Region||32-61 aa|
|Other Names||cAMP-specific 3', 5'-cyclic phosphodiesterase 4A, DPDE2, PDE46, PDE4A, DPDE2|
|Target/Specificity||This PDE4A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 32-61 amino acids from the N-terminal region of human PDE4A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PDE4A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.|
|Cellular Location||Isoform 1: Cytoplasm, perinuclear region. Isoform 4: Membrane; Peripheral membrane protein. Note=Isoform 4 has propensity for association with membranes Isoform 7: Cytoplasm. Membrane. Note=Predominantly cytoplasmic|
|Tissue Location||Isoform 1 is widely expressed. Isoform 2 is abundant in liver, stomach, testis, thyroid and adrenal glands. It is also found in placenta, kidney, pancreas, ovary, uterus, skin, monocytes, mast cells, macrophages, as well as in bronchial smooth muscle. Isoform 6 is expressed at high levels in the heart and small intestine. It is also found in the brain, kidney, spleen, colon, salivary gland, ovary and peripheral blood lymphocytes Isoform 7 is expressed predominantly in skeletal muscle and brain and at lower levels in the testis. Isoform 7 is expressed in the brain. Found in specific neuronal subpopulations in cortex, spinal cord and cerebellum (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. Cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. PDE4A is a class IV cAMP-specific PDE (summary by Milatovich et al., 1994 [PubMed 8009369]).
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Selige, J., et al. J. Cell. Physiol. 223(2):317-326(2010)
Bjorgo, E., et al. Mol. Cell. Biol. 30(7):1660-1672(2010)
Singh, D., et al. Respir. Res. 11, 26 (2010) :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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