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RTN1 Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - RTN1 Antibody (N-term) AP17182a
    RTN1 Antibody (N-term) (Cat. #AP17182a) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the RTN1 antibody detected the RTN1 protein (arrow).
    detail
  • WB - RTN1 Antibody (N-term) AP17182a
    RTN1 Antibody (N-term) (Cat. #AP17182a) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the RTN1 antibody detected the RTN1 protein (arrow).
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q16799
Other Accession NP_996734.1, NP_066959.1
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 83618 Da
Antigen Region 198-227 aa
Additional Information
Gene ID 6252
Other Names Reticulon-1, Neuroendocrine-specific protein, RTN1, NSP
Target/Specificity This RTN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 198-227 amino acids from the N-terminal region of human RTN1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRTN1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RTN1
Synonyms NSP
Function Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity.
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein
Tissue Location Expressed in neural and neuroendocrine tissues and cell cultures derived therefrom. Expression of isoform RTN1-C is strongly correlated with neuronal differentiation
Research Areas
Citations (0)
citation

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Background

This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. Alternatively spliced transcript variants encoding different isoforms have been identified. Multiple promoters rather than alternative splicing of internal exons seem to be involved in this diversity. [provided by RefSeq].

References

Rose, J. Phd, et al. Mol. Med. (2010) In press :
Fazi, B., et al. Oncogene 28(43):3814-3824(2009)
Melino, S., et al. Biochemistry 48(2):242-253(2009)
Di Sano, F., et al. J. Neurochem. 102(2):345-353(2007)
Iwahashi, J., et al. Biochem. Biophys. Res. Commun. 355(2):508-512(2007)

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$ 182.50
$ 70.00
Cat# AP17182a
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