|Application ||WB, E|
|Other Accession||NP_996734.1, NP_066959.1|
|Calculated MW||83618 Da|
|Antigen Region||198-227 aa|
|Other Names||Reticulon-1, Neuroendocrine-specific protein, RTN1, NSP|
|Target/Specificity||This RTN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 198-227 amino acids from the N-terminal region of human RTN1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RTN1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in neural and neuroendocrine tissues and cell cultures derived therefrom. Expression of isoform RTN1-C is strongly correlated with neuronal differentiation|
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Provided below are standard protocols that you may find useful for product applications.
This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. Alternatively spliced transcript variants encoding different isoforms have been identified. Multiple promoters rather than alternative splicing of internal exons seem to be involved in this diversity. [provided by RefSeq].
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Fazi, B., et al. Oncogene 28(43):3814-3824(2009)
Melino, S., et al. Biochemistry 48(2):242-253(2009)
Di Sano, F., et al. J. Neurochem. 102(2):345-353(2007)
Iwahashi, J., et al. Biochem. Biophys. Res. Commun. 355(2):508-512(2007)
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