ORAI3 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q9BRQ5 |
Other Accession | NP_689501.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 31499 Da |
Antigen Region | 1-30 aa |
Gene ID | 93129 |
---|---|
Other Names | Protein orai-3, Transmembrane protein 142C, ORAI3, TMEM142C |
Target/Specificity | This ORAI3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human ORAI3. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ORAI3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ORAI3 |
---|---|
Synonyms | TMEM142C |
Function | Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1. |
Cellular Location | Cell membrane; Multi-pass membrane protein |
Tissue Location | Expressed in both naive and effector T helper cells with higher levels in effector cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Key regulator or component of store-operated Ca(2+) channel and transcription factor NFAT nuclear import (By similarity).
References
Motiani, R.K., et al. J. Biol. Chem. 285(25):19173-19183(2010)
Bogeski, I., et al. Sci Signal 3 (115), RA24 (2010) :
Schindl, R., et al. Proc. Natl. Acad. Sci. U.S.A. 106(46):19623-19628(2009)
Lee, K.P., et al. Proc. Natl. Acad. Sci. U.S.A. 106(34):14687-14692(2009)
Frischauf, I., et al. J. Biol. Chem. 284(32):21696-21706(2009)
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