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ORAI3 Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - ORAI3 Antibody (N-term) AP17188a
    ORAI3 Antibody (N-term) (Cat. #AP17188a) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the ORAI3 antibody detected the ORAI3 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9BRQ5
Other Accession NP_689501.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 31499 Da
Antigen Region 1-30 aa
Additional Information
Gene ID 93129
Other Names Protein orai-3, Transmembrane protein 142C, ORAI3, TMEM142C
Target/Specificity This ORAI3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human ORAI3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsORAI3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ORAI3
Synonyms TMEM142C
Function Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1.
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Expressed in both naive and effector T helper cells with higher levels in effector cells.
Research Areas
Citations (0)
citation

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Background

Key regulator or component of store-operated Ca(2+) channel and transcription factor NFAT nuclear import (By similarity).

References

Motiani, R.K., et al. J. Biol. Chem. 285(25):19173-19183(2010)
Bogeski, I., et al. Sci Signal 3 (115), RA24 (2010) :
Schindl, R., et al. Proc. Natl. Acad. Sci. U.S.A. 106(46):19623-19628(2009)
Lee, K.P., et al. Proc. Natl. Acad. Sci. U.S.A. 106(34):14687-14692(2009)
Frischauf, I., et al. J. Biol. Chem. 284(32):21696-21706(2009)

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$ 182.50
$ 70.00
Cat# AP17188a
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