|Application ||WB, E|
|Other Accession||Q3C1E9, Q9CQE6, Q2KIG1, NP_054753.1|
|Predicted||Bovine, Mouse, Chicken|
|Calculated MW||22969 Da|
|Antigen Region||140-168 aa|
|Other Names||Histone chaperone ASF1A, Anti-silencing function protein 1 homolog A, hAsf1, hAsf1a, CCG1-interacting factor A, CIA, hCIA, ASF1A|
|Target/Specificity||This ASF1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140-168 amino acids from the C-terminal region of human ASF1A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ASF1A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.|
|Tissue Location||Ubiquitously expressed.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair. [provided by RefSeq].
Jasencakova, Z., et al. Mol. Cell 37(5):736-743(2010)
Newton-Cheh, C., et al. Nat. Genet. 41(4):399-406(2009)
Banumathy, G., et al. Mol. Cell. Biol. 29(3):758-770(2009)
Ambagala, A.P., et al. J. Virol. 83(1):200-209(2009)
Pilyugin, M., et al. PLoS ONE 4 (12), E8328 (2009) :
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