|Application ||WB, E|
|Calculated MW||119565 Da|
|Antigen Region||623-652 aa|
|Other Names||Apoptosis-stimulating of p53 protein 1, Protein phosphatase 1 regulatory subunit 13B, PPP1R13B, ASPP1, KIAA0771|
|Target/Specificity||This PPP1R13B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 623-652 amino acids from the Central region of human PPP1R13B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PPP1R13B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo.|
|Cellular Location||Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Some fraction is nuclear|
|Tissue Location||Reduced expression in breast carcinomas expressing a wild-type TP53 protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor.
Figl, A., et al. Mutat. Res. 702(1):8-16(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Zhao, J., et al. Hepatology 51(1):142-153(2010)
Agirre, X., et al. Oncogene 25(13):1862-1870(2006)
Liu, Z.J., et al. Biochim. Biophys. Acta 1756(1):77-80(2005)
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