|Application ||WB, E|
|Other Accession||NP_002888.1, NP_058520.1|
|Calculated MW||44505 Da|
|Antigen Region||224-252 aa|
|Other Names||RNA-binding motif, single-stranded-interacting protein 1, Single-stranded DNA-binding protein MSSP-1, Suppressor of CDC2 with RNA-binding motif 2, RBMS1, C2orf12, MSSP, MSSP1, SCR2|
|Target/Specificity||This RBMS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 224-252 amino acids from the Central region of human RBMS1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RBMS1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||C2orf12, MSSP, MSSP1, SCR2|
|Function||Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNA replication.|
|Tissue Location||Highest amounts are found in placenta, lung and heart|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. These proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. Several transcript variants, resulting from alternative splicing and encoding different isoforms, have been described. A pseudogene for this locus is found on chromosome 12.
Qi, L., et al. Hum. Mol. Genet. 19(13):2706-2715(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Landers, J.E., et al. Proc. Natl. Acad. Sci. U.S.A. 106(22):9004-9009(2009)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
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