|Application ||WB, E|
|Other Accession||Q7M767, Q9D2M8, Q3SZ43, NP_003341.1|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||16363 Da|
|Antigen Region||75-104 aa|
|Other Names||Ubiquitin-conjugating enzyme E2 variant 2, DDVit 1, Enterocyte differentiation-associated factor 1, EDAF-1, Enterocyte differentiation-promoting factor 1, EDPF-1, MMS2 homolog, Vitamin D3-inducible protein, UBE2V2, MMS2, UEV2|
|Target/Specificity||This UBE2V2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 75-104 amino acids from the Central region of human UBE2V2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||UBE2V2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.|
|Tissue Location||Detected in placenta, colon, liver and skin. Detected at very low levels in most tissues|
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Provided below are standard protocols that you may find useful for product applications.
Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes.
Wen, R., et al. Plant Cell 20(1):213-227(2008)
Brun, J., et al. BMC Mol. Biol. 9, 24 (2008) :
Pastushok, L., et al. FEBS Lett. 581(28):5343-5348(2007)
Zhao, G.Y., et al. Mol. Cell 25(5):663-675(2007)
Wen, R., et al. Plant Mol. Biol. 61 (1-2), 241-253 (2006) :
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