SGCA Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q16586 |
Other Accession | NP_001129169.1, NP_000014.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 42875 Da |
Antigen Region | 239-266 aa |
Gene ID | 6442 |
---|---|
Other Names | Alpha-sarcoglycan, Alpha-SG, 50 kDa dystrophin-associated glycoprotein, 50DAG, Adhalin, Dystroglycan-2, SGCA, ADL, DAG2 |
Target/Specificity | This SGCA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 239-266 amino acids from the Central region of human SGCA. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SGCA Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SGCA |
---|---|
Synonyms | ADL, DAG2 |
Function | Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. |
Cellular Location | Cell membrane, sarcolemma; Single- pass type I membrane protein. Cytoplasm, cytoskeleton |
Tissue Location | Most strongly expressed in skeletal muscle. Also expressed in cardiac muscle and, at much lower levels, in lung. In the fetus, most abundant in cardiac muscle and, at lower levels, in lung Also detected in liver and kidney. Not expressed in brain |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a component of the dystrophin-glycoprotein complex (DGC), which is critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. Its expression is thought to be restricted to striated muscle. Mutations in this gene result in type 2D autosomal recessive limb-girdle muscular dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene.
References
Mendell, J.R., et al. Ann. Neurol. 68(5):629-638(2010)
Fernandez, K., et al. Am. J. Pathol. 176(1):416-434(2010)
Klinge, L., et al. Neuromuscul. Disord. 18(12):934-941(2008)
Delgado-Olguin, P., et al. Biochim. Biophys. Acta 1779(1):74-80(2008)
Rafii, M.S., et al. J. Cell. Physiol. 209(2):439-447(2006)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.