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NVL Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O15381 |
| Other Accession | NP_002524.2, NP_996671.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 95051 Da |
| Antigen Region | 796-823 aa |
| Gene ID | 4931 |
|---|---|
| Other Names | Nuclear valosin-containing protein-like, NVLp, Nuclear VCP-like protein, NVL |
| Target/Specificity | This NVL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 796-823 amino acids from the C-terminal region of human NVL. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NVL Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NVL (HGNC:8070) |
|---|---|
| Function | Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT (PubMed:22226966). Involved in both early and late stages of the pre- rRNA processing pathways (PubMed:26166824). Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus (PubMed:15469983, PubMed:16782053, PubMed:29107693, PubMed:26456651). Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity (PubMed:29107693, PubMed:26456651, PubMed:28416111). |
| Cellular Location | [Isoform 2]: Nucleus, nucleoplasm |
| Tissue Location | Widely expressed. Highest level of expression in heart, placenta, skeletal muscle, pancreas and retina |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)
Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)
Nagahama, M., et al. Biochem. Biophys. Res. Commun. 346(3):1075-1082(2006)
Nagahama, M., et al. Mol. Biol. Cell 15(12):5712-5723(2004)
Scherl, A., et al. Mol. Biol. Cell 13(11):4100-4109(2002)
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