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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PDGFB Antibody (C-term)   

PDGFB Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PDGFB Antibody (C-term) AP1721A
    The anti-PDGFB C-term Pab (Cat. #AP1721a) is used in Western blot to detect PDGFB in A375 cell lysate.
  • IF - PDGFB Antibody (C-term) AP1721A
    Confocal immunofluorescent analysis of PDGFB Antibody (C-term) (Cat#AP1721a) with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P01127
Other Accession NP_148937
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 27283 Da
Antigen Region 212-241 aa
Additional Information
Gene ID 5155
Other Names Platelet-derived growth factor subunit B, PDGF subunit B, PDGF-2, Platelet-derived growth factor B chain, Platelet-derived growth factor beta polypeptide, Proto-oncogene c-Sis, Becaplermin, PDGFB, PDGF2, SIS
Target/Specificity This PDGFB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 212-241 amino acids from the C-terminal region of human PDGFB.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPDGFB Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms PDGF2, SIS
Function Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity).
Cellular Location Secreted. Note=Released by platelets upon wounding
Tissue Location Expressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney. Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and lung.
Research Areas
Citations (0)

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PDGFB is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor alpha polypeptide, where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor.


Muller, C., et al., J. Biol. Chem. 278(20):18330-18335 (2003). Laprise, M.H., et al., Blood 100(10):3578-3587 (2002). Maire, G., et al., Cancer Genet. Cytogenet. 134(2):156-161 (2002). Andrae, J., et al., Biochem. Biophys. Res. Commun. 296(3):604-611 (2002). Ehrlich, H.P., et al., Cytokines Cell Mol Ther 7(3):85-90 (2002).

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Cat# AP1721A
(40 western blots)
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