|Application ||WB, E|
|Calculated MW||78214 Da|
|Antigen Region||284-311 aa|
|Other Names||E3 ubiquitin-protein ligase Praja-2, Praja2, 632-, RING finger protein 131, PJA2, KIAA0438, RNF131|
|Target/Specificity||This PJA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 284-311 amino acids from the Central region of human PJA2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PJA2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA- mediated long-term memory processes.|
|Cellular Location||Cytoplasm. Cell membrane. Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Localizes at the cytoplasmic side of endoplasmic reticulum and Golgi apparatus Expressed in the postsynaptic density region of synapses (By similarity). Colocalizes with PRKAR2A and PRKAR2B in the cytoplasm and the cell membrane.|
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Provided below are standard protocols that you may find useful for product applications.
PJA2 has E2-dependent E3 ubiquitin-protein ligase activity (By similarity).
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Sasaki, A., et al. J. Biol. Chem. 277(25):22541-22546(2002)
Yu, P., et al. Genomics 79(6):869-874(2002)
Mishra, L., et al. Oncogene 15(19):2361-2368(1997)
Nakayama, M., et al. J. Neurosci. 15 (7 PT 2), 5238-5248 (1995) :
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